Natalie Thiex

Natalie Thiex, PhD

Associate Professor
South Dakota State University
Biology & Microbiology
(605) 688-5874

Dr. Thiex received her PhD in Toxicology from the University of Michigan in 2008.  She researches signal transduction and vesicular trafficking in macrophages.  Her laboratory uses live- and fixed-cell microscopy, flow cytometry and molecular tools to understand the molecular mechanisms of two driving biology problems.  The first is to discover the intracellular mechanisms of foam cell dysfunction in atherosclerosis, and the second is to understand the cellular growth control through intracellular trafficking of signaling molecules leading to their degradation and signal attenuation.  Dr. Thiex teaches genetics and cancer biology courses using active learning strategies and also mentors undergraduate and graduate students in her cell biology laboratory.

Areas of expertise:
Mammalian cell biology, macrophage biology, signal transduction, vesicular trafficking, lipid droplet metabolism, macropinocytosis, toxicology, molecular epidemiology

Selected publications:
Specker B, Thiex NW, Sudhagoni RG. “Does Exercise Influence Pediatric Bone? A Systematic Review.” Clin Orthop Relat Res. 2015 Nov; 473(11):3658-72. doi: 10.1007/s11999-015-4467-7

Wimberly A, and Thiex NW (2015). “The Distance Women Travel – Women and Healthcare in South Dakota.”  In Redlin, M., C. Stewart-Nunez and J. Barst, eds. Influence, Action and Voice: Contemporary South Dakota Women. SD Agricultural Museum Publications.

Binkley, TL, Thiex NW, Specker B. “Validation of Drinking Water Disinfection By-Product Exposure Assessment for the National Children’s Study.” Journal of Exposure Science And Environmental Epidemiology. 2014 Jul 16. doi: 10.1038/jes.2014.51. PMID: 25027449

Thiex NW, Kalkwerf HJ, Specker BL (2010). “Vitamin D Metabolism in Pregnancy and Lactation.” In  JW Pike, D Feldman and J Adams (eds.), Vitamin D (3rd ed.).

Specker BL, Sudhagoni R, and Thiex NW (2010).  “Calcium Intake Influences the Bone Response to Exercise in Children.”  In J Anderson (ed.), Diet Nutrition and Bone.

Thiex NW, Chames MC, Loch-Caruso RK.  “Tissue-Specific Induction of COX-2 and Prostaglandins in Lipopolysaccharide-Stimulated Extraplacental Human Gestational Membranes in a 2-Chamber Transwell Culture System.” Reproductive Sciences. 2010 Dec; 17(12):1120-9. PMCID: PMC3096444

Thiex NW, Chames MC, Loch-Caruso RK.  “Tissue-specific cytokine release from human extra-placental membranes stimulated by lipopolysaccharide in a two-compartment tissue culture system.”  Reproductive Biology and Endocrinology 2009, 7:117 (26 October 2009). PMCID: PMC2774314

Martin A, Beare T, Thiex NW, Holm RJ, Specker B. “South Dakota's role in the National Children's Study.” S D Med. 2009 Jun 62(6):245-7. PMID: 19650279

Park CG, Thiex NW, Lee KM, Szot GL, Bluestone JA, Lee KD.  “Targeting and blocking B7 costimulatory molecules on antigen-presenting cells using CTLA4Ig-conjugated liposomes: in vitro characterization and in vivo factors affecting biodistribution.”  Pharm Res. 2003 Aug; 20(8):1239-48. PMID: 12948022


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