Surtaj Iram

Surtaj Iram, PhD

Assistant Professor
South Dakota State University
Chemistry & Biochemistry
(605) 688-5447

Dr. Iram obtained his PhD in Biochemistry from the University of Illinois, Urbana-Champaign.  For his postdoctoral training he worked at the Cancer Institute at Columbia University in New York followed by Cancer Research Institute at Queen’s University, Kingston, ON. Dr. Iram was working as a Research Associate at the Stritch School of Medicine at Loyola University Chicago before joining South Dakota State University as a tenure-track Assistant Professor in the Department of Chemistry & Biochemistry.

Areas of expertise:
High-throughput screening approaches for drug discovery & development, biomolecular engineering for drug discovery, regulation and structure-function studies of ABC membrane transporters, cancer biology and cancer therapeutics, multidrug resistance in cancer

Selected publications:
Peterson BG, Tan KW, Osa-Andrews B, Iram SH. High-Content Screening of Clinically Tested Anticancer Drugs Identifies Novel Inhibitors of Human MRP1 (ABCC1). Pharmacological Research. 2017 Feb 28;119:313-326. PMID: 28258008

Iram SH, Gruber SJ, Thomas DD and Robia SL. ABC Transporter Structure Changes Detected by Intramolecular Fluorescence Resonance Energy Transfer for High-throughput Screening. Molecular Pharmacology. 2015 Jul; 88(1): 84-94.

Iram SH and Cole SPC. Differential rescue of Lys513 and Lys516 processing mutants of MRP1 (ABCC1) by chemical chaperones reveals different domain-domain interactions of the transporter. Biochim Biophys Acta. 2014 Mar;1838(3):756-65.

Iram SH and Cole SPC. Mutations in cytoplasmic loop 5 cause misfolding in multiple domains of the multidrug and organic anion transporter MRP1 (ABCC1). J. Biol. Chem. 2012 Mar 2;287(10):7543-55.

Iram SH and Cole SPC. Expression and function of human MRP1 (ABCC1) is dependent on amino acids in cytoplasmic loop 5 and its interface with nucleotide
binding domain 2. J. Biol. Chem. 2011 Mar 4;286(9).

Momcilovic M, Iram SH, Liu Y, and Carlson M. Roles of the glycogen-binding domain and Snf4 in glucose inhibition of SNF1 protein kinase. J. Biol. Chem. 2008 Jul 11;283(28):19521-9. (co-1st author)

Rudolph MJ, Amodeo GA, Iram SH, Hong SP, Pirino G, Carlson M, and Tong L. Structure of the Bateman2 domain of yeast Snf4: dimeric association and relevance
for AMP binding. Structure 2007 Jan;15(1).

Iram SH and Cronan JE. The beta-oxidation systems of Escherichia coli and Salmonella enterica are not functionally equivalent. J. Bacteriol. 2006  Jan;188(2):599-608.

Iram SH and Cronan JE. Unexpected functional diversity among FadR fatty acid transcriptional regulatory proteins. J. Biol. Chem. 2005 Sep 16;280(37):32148-56.

 

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