Feng Li, PhD
The primary focus of Dr. Li's research lab is to elucidate the dynamic and intricate interactions between viral pathogens and hosts toward better understanding the cellular and molecular mechanisms by which host responses to control viral pathogenesis or enhance disease and its transmission. A particular interest of the lab is to collect and translate such information to develop effective next-generation vaccine and antiviral therapeutic strategies. A diverse spectrum of enveloped viruses that is currently investigated in the lab includes various types of human and animal influenza viruses (A, B, C, and D), ZIKA virus, and HIV-1. A multidisciplinary approach consisting of virology, cell and molecular biology, bioinformatics, structural biology, and genetics and evolutionary biology is employed to study these viral pathogens that have a significant impact on human and animal health
Areas of expertise:
Virology, vaccine, antiviral therapeutics, influenza virus, Zika virus, HIV, retrovirus
Jieshi Yu, Busha Hika, Runxia Liu, Zizhang Sheng, Benjamin Hause, Feng Li, and Dan Wang. 2017. The Hemagglutinin-Esterase-Fusion Glycoprotein is a Primary Determinant of the Exceptional Thermal and Acid Stability of Influenza D Virus. mSphere, Vol. 4:2
Shao-Lun Zhai, He Zhang, Sheng-Nan Chen, Xia Zhou, Tao Lin, Runxia Liu, Dian-Hong Lv, Xiao-Hui Wen, Wen-Kang Wei, Dan Wang, and Feng Li. 2017. Influenza D virus in animal species in Guangdong Province, Southern China. Emerging Infectious Disease. 2017;23(8):1392-1396. https://dx.doi.org/10.3201/eid2308.170059
Namita Mitra1, Natalia Cernicchiaro, Siddartha Torres3, Feng Li, Ben M. Hause. 2016. Metagenomic characterization of the virome associated with bovine respiratory disease in feedlot cattle identified novel viruses and suggests an etiologic role for influenza D virus. Journal of General Virology 97: 1771-1784, doi: 10.1099/jgv.0.000492
Yu K, Ma X, Sheng Z, Qi L, Liu C, Wang D, Huang B, Feng Li, Song M. 2016. Identification of goose-origin parvovirus as a cause of newly emerging beak atrophy and dwarfism syndrome in ducklings. J Clin Microbiol 54:1999–2007. doi:10.1128/JCM.03244-15.
Sreenivasan C, Thomas M, Sheng Z, Hause BM, Collin EA, Knudsen DE, Pillatzki A, Nelson E, Wang D, Kaushik RS, and Feng Li. 2015. Replication and transmission of novel bovine influenza D virus in guinea pig model. J. Virol. 2015 9(23):11990-2001. doi: 10.1128/JVI.01630-15. Epub 2015 Sep 16. PMCID: PMC4645331.
Collin EA, Sheng Z, Lang Y, Ma W, Hause BM, and Feng Li. 2015. Cocirculation of two distinct genetic and antigenic lineages of proposed influenza D virus in cattle. J. Virol 89:1036 –1042
Zhiguang Ran, Huigang Shen, Yuekun Lang, Elizabeth Kolb, Nuri Turan, Laihua Zhu, Jingjiao Ma, Bhupinder Bawa, Qinfang Liu, Haixia Liu, Megan Quast, Gabriel Sexton, Florian Krammer, Ben Hause, Jane Christopher-Hennings, Eric Nelson, Juergen Richt, Feng Li, and Wenjun Ma. 2015. Domestic pigs are susceptible to infection with influenza B viruses. J. Virol. 2015 Feb 11. pii: JVI.00059-15. [Epub ahead of print]
Ben M. Hause, Emily A. Collin, Runxia Liu, Zizhang Sheng, and Feng Li, 2014. Characterization of a Novel Influenza Virus in cattle and swine: proposal for a new genus in the Orthomyxoviridae family. mBio 5, e00031 (2014). PMCID: PMC3958797.
Andrew J Demers, Zhiguang Ran, Qiji Deng, Dan Wang, Brody Edman, Wuxun Lu, and Feng Li. 2014. Palmitoylation Is Required for Intracellular Trafficking of Influenza B Virus NB Protein and Efficient Influenza B Growth In Vitro. Journal of General Virology. 2014 Jun;95(Pt 6):1211-20. doi: 10.1099/vir.0.063511-0. Epub 2014 Mar 26.
Ben M. Hause, Mariette Ducatez, Emily A. Collin, Zhiguang Ran, Runxia Liu, Zizhang Sheng,Anibal Armien, Bryan Kaplan, Suvobrata Chakravarty, Adam Hoppe, Richard J. Webby, Randy R. Simonson, Feng Li, 2013. Isolation of a novel swine influenza virus from Oklahoma in 2011 which is distantly related to human influenza C viruses. PLOS PATHOGENS 9(2): e1003176. doi:10.1371/journal.ppat.1003176. PMCID: PMC3567177
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