Mark Larson, PhD

Associate Professor
Augustana University
Biology
(605) 274-4700

Dr. Larson teaches Introductory Biology, Biochemistry, Pharmacology and Cell Biology. His research focuses on platelets, platelet function, and platelet biogenesis. He is also the pre-professional advisor for clinical lab science. He received his bachelor’s degree in biology and chemistry at Concordia College and his Ph.D. in pharmacology from the University of North Carolina at Chapel Hill, and he worked as a post-doctoral research fellow at the Centre for Cardiovascular Research at the University of Birmingham (UK).

Areas of expertise:
Cell biology, biochemistry, hematology, platelet biology

Selected publications:
Lamichhane, S., Anderson, J.A., Remund, T., Sun, H., Larson, M.K., Kelly, P., Mani, G. Responses of endothelial cells, smooth muscle cells, and platelets dependent on the surface topography of polytetrafluoroethylene. J Biomed Mater Res A. 2016; 104:2291-304. doi: 10.1002/jbm.a.35763.

Thiruppathi, E., Larson, M.K., Mani, G.  Surface Modification of CoCr Alloy Using Varying Concentrations of Phosphoric and Phosphonoacetic Acids: Albumin and Fibrinogen Adsorption, Platelet Adhesion, Activation, and Aggregation Studies. Langmuir 2015; 31: 358-370.

Wachira, J.K., Larson, M.K., Harris, W.S. Omega-3 Fatty Acids Affect Hemostasis But Do Not Increase Risk for Bleeding: Clinical Observations and Mechanistic Insights Br. J. Nutr. 2014; 111:1652-62.

Larson, M.K., Tormoen, G.W., *Weaver, L.J., *Luepke, K.J., *Patel, I.A., *Hjelmen, C.E., *Ensz, N.M., *McComas, L.S., McCarty, O.J.T.  Exogenous modification of platelet membranes with EPA and DHA reduces platelet procoagulant activity and thrombus formation. Amer. J. Phys – Cell Phys., 2013; 304:C273-C279

Keenan, A.H., Pedersen, T.L., Fillaus, K., Larson, M.K., Shearer, G.C., Newman, J.W.  Basal omega-3 fatty acid status affects fatty acid and oxylipin responses to high-dose n3 HUFA in healthy volunteers. J. Lipid Res, 2012; 53:1662-1669.

Larson, M.K., Shearer, G.C., Ashmore, J.H., *Anderson-Daniels, J.M., *Graslie, E.L., *Tholen, J.T., *Vogelaar, J.L., *Korth, A.J., Nareddy, V., Sprehe, M., Harris, W.S. Omega-3 fatty acids modulate collagen signaling in human platelets.  Prostaglandins Leukot Essent Fatty Acids, 2011; 84:93-98.

Thon, J.N., Montalvo, A., Patel-Hett, S.R., Devine, M.T., Richardson, J.L., Ehrlicher, A., Larson, M.K., Hoffmeister, K., Hartwig, J.H., Italiano Jr., J.E.  Identification of intermediate stages in proplatelet maturation and a mechanism of platelet release.  J. Cell Biol., 2010; 191:861-74.

Block R.C., Duff R., Lawrence P., Kakinami L., Brenna J.T., Shearer G.C., Meednu N., Mousa S., Friedman A., Harris W.S., Larson M., and Georas S.  The effects of EPA, DHA, and aspirin ingestion on plasma lysophospholipids and autotaxin.  Prostaglandins Leukot Essent Fatty Acids.  2010; 82:87-95.     

Wang, Z., Holly, S.P., Larson, M.K., Liu, J., Yuan, W., Chrzanowska-Wodnicka, M., White II, G.C., and Parise, L.V. Rap1b Is Critical for GPVI- but not ADP Receptor-Mediated alpha 2 beta 1 Activation.  J. Thromb. Haemost. 2009; 7:693-700. 

Larson, M.K., *Ashmore, J.H., *Harris, K.A., *Vogelaar, J.L., Pottala, J.V., Sprehe, M., and Harris, W.S.  Effects of Omega-3 Acid Ethyl Esters and Aspirin, Alone and in Combination, on Platelet Function in Healthy Subjects.  Thrombosis and Haemostasis. 2008;100:634-41.

* denotes undergraduate student

 

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