Adam Hoppe, PhD
Dr. Hoppe’s research focuses on the biophysical mechanisms of cell-surface receptor signaling governing cell growth and function. He is developing new imaging technologies to quantify molecular interactions on the surface and inside living cells. This information is being used to create mechanistic and mathematical models of signaling pathways.
Areas of expertise:
Genome editing, FRET, TIRF, phagocytosis, endocytosis, M-CSF, CSF-1, GM-CSF
Cypher LR, Bielecki TA, Huang L, An W, Iseka F, Tom E, Storck MD, Hoppe AD, Band V, Band H. CSF-1 receptor signalling is governed by pre-requisite EHD1 mediated receptor display on the macrophage cell surface. Cell Signal. 2016 Sep;28(9):1325-35. doi: 10.1016/j.cellsig.2016.05.013.
Lin J, Kurilova S, Scott BL, Bosworth E, Iverson BE, Bailey EM, Hoppe AD. TIRF imaging of Fc gamma receptor microclusters dynamics and signaling on macrophages during frustrated phagocytosis. BMC Immunol. 2016 Mar 12;17:5. doi: 10.1186/s12865-016-0143-2. (featured article)
Scott, B. L. and Hoppe, A. D. (2015) “Optimizing fluorescent protein trios for 3-Way FRET imaging of protein interactions in living cells,” Scientific Reports
Lou, J., Low-Nam, S., Kerkvliet, J., and Hoppe, A. D., (2014) “Delivery of the CSF-1R to the lumen of macropinosomes promotes its destruction in macrophages.” J. Cell Sci 127, 5228-5239.
Hoppe, A.D., Scott, B.L., Welliver, T.P., Straight, S.W., Swanson, J.A. (2013). N-Way FRET Microscopy of Multiple Protein-Protein Interactions in Live Cells. PLOS one. 8(6): e64760
Beemiller, P., Zhang, Y., Mohan, S., Levinsohn, J., Gaeta, I., Hoppe, A. D., Swanson, J. A., (2010). A Cdc42 Activation Cycle Coordinated by PI 3-kinase during Fc Receptor-mediated Phagocytosis. Mol. Biol. Cell. 21(3) 470-480.
Yoshida, S., Hoppe, A. D., Araki, N., Swanson J. A., (2009). Sequential signaling in plasma-membrane domains during macropinsome formation in macrophages. J. Cell. Sci. 122:3250-3261.
Hoppe, A. D., Shorte, S. L., Swanson, J. A., Heintzmann, R. (2008). 3D-FRET Reconstruction Microscopy for Analysis of Dynamic Molecular Interactions in Live Cells. Biophys. J. 95:400-418.
Swanson J. A. and Hoppe, A. D. (2004). The Coordination of Signaling during Fc Receptor-mediated Phagocytosis. J Leuk. Biol. (76(6):1093-103)
Hoppe, A. D., and Swanson, J. A. (2004). Cdc42, Rac1 and Rac2 Display Distinct Patterns of Activation during Phagocytosis. Mol. Biol. Cell. 15(8), 3509-19.
Return to Leadership main page.