Lance Lee, PhD

Associate Scientist
Sanford Research
Pediatrics & Rare Diseases
(605) 312-6410

Dr. Lee obtained his BS in Biochemistry from Boston College in 1995, his MS in Genetics from the University of Connecticut in 1997, and his PhD in Cell and Developmental Biology from Stony Brook University in 2004.  He then did a postdoctoral fellowship at Boston Children’s Hospital / Harvard Medical School, where he studied genetic causes of primary ciliary dyskinesia in mouse models.  He is currently a faculty member in the Pediatrics and Rare Diseases Group at Sanford Research, where his lab studies the genetic and molecular mechanisms underlying motile cilia disorders.  He also serves as the Director of Higher Education for Sanford Research.

Areas of expertise:
Mammalian genetics, motile cilia biology, primary ciliary dyskinesia

Selected publications:
Casey W. McKenzie, Branch Craige, Tiffany V. Kroeger, Rozzy Finn, Todd A. Wyatt, Joseph H. Sisson, Jacqueline A. Pavlik, Gregory M. Hendricks, Lara Strittmatter, George B. Witman, and Lance Lee.  (2015) Cfap54 is required for proper ciliary motility and assembly of the central pair apparatus in mice.  Molecular Biology of the Cell, 26: 3140-3149.

Rozzy Finn, Claire C. Evans, and Lance Lee.  (2014)  Strain-dependent brain defects in mouse models of primary ciliary dyskinesia with mutations in Pcdp1 and Spef2Neuroscience 277: 552-567.

Casey W. McKenzie, Joshua M. Klonoski, Taylor Maier, Glenda Trujillo, Peter F. Vitiello, Victor C. Huber, and Lance Lee.  (2013)  Enhanced Response to Pulmonary Streptococcus pneumoniae Infection is Associated with Primary Ciliary Dyskinesia in Mice Lacking Pcdp1 and Spef2.  Cilia, 2: 18.

Anu Sironen, Noora Kotaja, Howard Mulhern, Todd A. Wyatt, Joseph H. Sisson, Jacqueline A. Pavlik, Mari Miiluniemi, Mark D. Fleming, and Lance Lee.  (2011).  Loss of SPEF2 function in mice results in spermatogenesis defects and primary ciliary dyskinesia. Biology of Reproduction, 85: 690-701. 

Lance Lee, Dean R. Campagna, Jack L. Pinkus, Howard Mulhern, Todd A. Wyatt, Joseph H. Sisson, Jacqueline A. Pavlik, Geraldine S. Pinkus, and Mark D. Fleming.  (2008).  Primary ciliary dyskinesia in mice lacking the novel ciliary protein Pcdp1.  Molecular and Cellular Biology 28: 949-957.

Lance Lee, C. Anthony DeBono, Dean R. Campagna, David C. Young, D. Branch Moody, and Mark D. Fleming.  (2007).  Loss of the acyl-CoA binding protein (Acbp) results in fatty acid metabolism abnormalities in mouse hair and skin.  Journal of Investigative Dermatology 127: 16-23.

Jen-Chih Hsieh*, Lance Lee*, Liqun Zhang, Stephen Wefer, Kristen Brown, Charles DeRossi, Mary E. Wines, Thomas Rosenquist, and Bernadette C. Holdener.  (2003).  Mesd encodes a novel LRP5/6 chaperone essential for specification of mouse embryonic polarity.  Cell 112: 355-367.  *Authors contributed equally to this article.

Mary E. Wines*, Lance Lee*, Manpreet S. Katari, Liqun Zhang, Signa Perkins, Michael Feldman, Ying Shi, Richard McCombie, and Bernadette C. Holdener.  (2001).  Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis.  Genomics 72: 88-98.  *Authors contributed equally to this article.

 

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